Intra-articular Injection in Osteoarthritis
نویسندگان
چکیده
منابع مشابه
Intra-articular corticosteroid injection for osteoarthritis
Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...
متن کاملIntra-articular therapy in osteoarthritis.
The medical literature was reviewed from 1968-2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy,...
متن کاملIntra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model
OBJECTIVES Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhi...
متن کاملLocal intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
INTRODUCTION Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo. Since the systemic use of rapamycin is associated with numerous side effects, the goal of the curr...
متن کاملIntra-articular corticosteroid injections in osteoarthritis: do
Intra-articular (IA) corticosteroids are recommended in several guidelines for the treatment of patients with knee osteoarthritis (OA). 2 They are also widely used: a recent survey of rheumatologists in the United States suggesting that over 95% use them at least ‘sometimes’ and 53% ‘frequently’. Before considering mechanisms of action of IA corticsteroids we should first consider the evidence ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1947
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4490.159-b